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Coronavirus vaccine patch shows promise in mice


When tested in mice, the vaccine—delivered through a fingertip-sized patch—produces antibodies specific to SARS-CoV-2 at quantities thought to be sufficient for neutralizing the virus. The paper appears in EBioMedicine and is the first study describing a candidate vaccine for COVID-19 to be published after critique from fellow scientists at outside institutions. The researchers were able to act quickly because they had already laid the groundwork during earlier coronavirus epidemics. “We had previous experience on SARS-CoV in 2003 and MERS-CoV in 2014. These two viruses, which are closely related to SARS-CoV-2, teach us that a particular protein, called a spike protein, is important for inducing immunity against the virus. We knew exactly where to fight this new virus,” says co-senior author Andrea Gambotto, associate professor of surgery at the University of Pittsburgh School of Medicine (UPMC).

Futurity - April 6, 2020

View the full story here: https://www.futurity.org/vaccine-against-sars-cov-2-covid-19-2327182-2/