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One vaccine shot leaves many vulnerable to Covid variants, UK study finds

Individuals who receive one shot of the Covid-19 vaccine and have never been infected by the virus could be very vulnerable to new variants, according to a new UK study. Researchers from Imperial College London, Queen Mary University of London and University College London looked at immune responses in healthcare workers who had received one shot of the BioNTech/Pfizer vaccine. The scientists found that people who had not previously been infected by Covid-19 showed very low levels of neutralising antibodies against the original strain from Wuhan, the B.1.1.7 variant first identified in Kent and B.1.351 from South Africa. By contrast, those who had previously had mild or asymptomatic infection and then received a single dose appeared to have greatly enhanced protection against both B.1.1.7 and B.1.351, demonstrating high neutralising antibodies and a strong response by T cells, which remember past infection.

Financial Times - April 30, 2021

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