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Prior SARS-CoV-2 infection boosts response to variants after first vaccine dose

A single dose of vaccine boosts protection against SARS-CoV-2 coronavirus variants, but only in those with previous COVID-19, a study has found. In those who have not previously been infected and have so far only received one dose of vaccine the immune response to variants of concern may be insufficient. The findings, published today in the journal Science and led by researchers at Imperial College London, Queen Mary University of London and University College London, looked at immune responses in UK healthcare workers at Barts and Royal Free hospitals following their first dose of the Pfizer/BioNTech vaccine.* They found that people who had previously had mild or asymptomatic infection had significantly enhanced protection against the Kent and South Africa variants, after a single dose of the mRNA vaccine. In those without prior COVID-19, the immune response was less strong after a first dose, potentially leaving them at risk from variants.

Imperial College London - April 30, 2021

View the full story here: https://www.imperial.ac.uk/news/220613/prior-sars-cov-2-infection-boosts-response-variants