Monoclonal antibody could inform development of pan-coronavirus vaccines

Researchers in the United States have demonstrated the potential of a monoclonal antibody to inform the design of pan-coronavirus vaccines that could prevent the outbreak of future pandemics such as coronavirus disease 2019 (COVID-19). The team from the Fred Hutchinson Cancer Research Center in Seattle, Washington and The Scripps Research Institute in La Jolla, California, had already shown that the antibody – called CV3-25 –neutralizes the B.1.351 (beta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Furthermore, the antibody cross neutralized SARS-CoV-1 and displayed cross-reactive binding to recombinant proteins derived from the human coronaviruses OC43 and HKU.