Heterologous vaccine schedule provides extraordinary response to third dose of coronavirus vaccines

A third, booster dose of either the ChAdOx1 nCoV-19 (Oxford-AstraZeneca), BNT162b2 (Pfizer-BioNTech), AD26.COV2-S (Janssen) or CoronaVac (SinoVac) coronavirus vaccine induce a significant increase in antibody levels in those who have previously received two doses of CoronaVac. The strongest responses were seen with mixed schedules, including against the Delta and Omicron variants of concern. The results from a study funded by the Ministry of Health, Brazil, and conducted by researchers from Brazil and the University of Oxford have today been published as a peer-reviewed paper in the Lancet.