Safety and antibody responses to COVID-19 vaccines in an older community

Clinical trials and population-based studies of COVID-19 vaccines reveal exceptional safety and short-term efficacy. While clinical trials included older people aged over 70 years, the COVID-19 mortality rate was higher, particularly in those with comorbid conditions. In Canada, the interval between two vaccine doses was extended to allow immunization of more people, which raised concerns regarding the efficacy of vaccines. While studies noted the benefits of extended duration, little is known about that in the older population.