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A new coronavirus found in Swedish bank voles

The current study discusses the discovery of a novel beta-CoV in Swedish bank voles and presents its full sequence for the first time. The failure to detect this virus using a published pan-CoV PCR test is traceable to the highly divergent RNA sequence of the Grimso virus. The use of specific spike gene primers in the customized PCR used in the present study yielded several samples over the three-year study period. The two complete sequences obtained in this study showed almost 3.5% non-identity, which amounted to about 1,340 differences at the nucleotide level. This exceeds the expected rate of nucleotide substitution over three years. Either several strains of the Grimso virus are co-circulating in this rodent species, or the true reservoir of this virus includes other species that regularly transmit it to bank voles. The prevalence of the Grimso virus in this rodent species was about 3.4%, thus suggesting that this animal is a suitable host for the virus. As a result, the Grimso virus presents a potential zoonotic host for spillover events between bank voles and human beings.

News-Medical.Net - June 9, 2022

View the full story here: https://www.news-medical.net/news/20220607/A-new-coronavirus-found-in-Swedish-bank-voles.aspx