Why Obesity May Stack the Deck for COVID-19 Risk

“My lungs were quite badly affected,” says O’Rahilly, 62, who spent almost a week getting extra oxygen in what’s known as a high-intensity care unit in the U.K. The experience got him thinking: While about 80% of cases of COVID-19 can be treated at home, why do some people, including him, wind up with more severe infections? Besides his age, O’Rahilly knew he had another strike against him when it comes to COVID-19 infection: his weight. His BMI, or body mass index, is over 30. O’Rahilly, who directs the MRC Metabolic Diseases Unit at Cambridge University, is considered one of the world’s leading obesity researchers. He was knighted in 2013 by Queen Elizabeth II for his work, which includes the discovery of a genetic condition that robs the body of the hormone leptin, which controls appetite and weight. And so after his brush with the coronavirus, he started digging into exactly what it is about obesity that makes it so risky for a COVID-19 infection